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This research proposal investigates how neuroplasticity-informed strategies can transform high school mathematics education through a systematic review and theoretical analysis of existing literature. By synthesizing peer-reviewed studies, theoretical frameworks, and documented interventions, this study aims to develop a comprehensive framework for neuroplasticity-based mathematics instruction. The research examines three key areas: the alignment of instructional strategies with cognitive development, the role of growth mindset, and evidence-based practices for applying neuroscientific insights in mathematics education. This study bridges neuroscience and education, contributing to brain-based pedagogy literature while providing practical guidelines for leveraging neuroplasticity in mathematics education. The findings will offer both theoretical foundations and practical applications for enhancing mathematical learning through neuroplasticity principles.