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Research has shown that teacher turnover is affected by working conditions at school sites, including administrative leadership and school culture. Large-scale shifts in curriculum and instructional philosophy are an understudied element of a teacher’s working conditions. Instructional shifts often require teachers to work additional hours aligning their practice to a new curricular direction, potentially increasing teacher turnover. However, instructional shifts also potentially empower teachers to be more effective in the classroom by providing more professional development and support, potentially reducing teacher turnover. Through its quasi-experimental examination of a credibly exogenous literacy overhaul in California’s lowest-performing elementary schools, this project sheds light on the broader relationship between instructional change and teacher turnover.