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This study evaluates V+Care, a high-fidelity virtual reality simulation designed to teach intravenous infusion skills. Using Flow Theory, Cognitive Load Theory, and the Technology Acceptance Model, the research models how experiential VR features—immersion, presence, realism, and interactivity—affect flow, usability, and learning outcomes. Using a mixed-methods approach (N = 24), the study combines structural equation modeling with qualitative user feedback. Results indicate strong predictive relationships between virtual design elements, subjective experience, and objective knowledge gains (45% improvement). Qualitative themes underscore the importance of interface clarity, gamification, and realistic feedback. The findings provide design insights for scalable VR training in healthcare and demonstrate VR’s educational potential for professional training.