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Many undergraduate science instructors operate within “neutrality” culture, which can translate into harmful teaching practices that do not acknowledge the identities and experiences of minoritized students. Additionally, instructors are currently under heightened scrutiny regarding what and how they teach due to multiple and ongoing “educational gag orders” on topics that are deemed “divisive.” Included among “divisive” topics under scrutiny are those pertaining to sex, sexuality, reproduction, and gender (SSRG), which are commonplace in many undergraduate biology curricula. This study explored the connection between biology instructors’ frames regarding the nature of science and how these frames manifest in their teaching of SSRG topics amid sociopolitical pressures to teach the sciences in “neutral” ways.