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This meta-analysis explores the effect sizes of computer-assisted word reading interventions on different reading-related outcomes (i.e., letter knowledge, phonemic awareness, word reading and pseudoword decoding, sentence and text reading, and spelling). The meta-analysis included 67 studies published between 1995 to 2023 and involved elementary school students from diverse linguistic backgrounds. The analysis found evidence of transfer effects on reading comprehension, with a small but significant pooled effect size of g = 0.21 (k = 67). The analysis showed a high heterogeneity of effect sizes, particularly within studies, and suggested that intervention duration, pseudo-word level as outcome, and reading speed may moderate results. The outcomes of this synthesis indicate that computer-based word-reading interventions positively affect reading accuracy and fluency.