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In this meta-analysis, we systematically examined the relation of vocabulary with reading and its componential skills—word reading, reading comprehension, phonological awareness, orthographic awareness, and background knowledge. A total of 1,119 studies comprising 4,543 effect sizes from 1,464 unique samples of participants were included. Results showed positive relations with word reading (r = .39), reading comprehension (r = .54), phonological awareness (r = .37), orthographic awareness (r = .22), and background knowledge (r = .48). Furthermore, the relations of vocabulary with word reading and reading comprehension were significantly moderated by orthographic depth, developmental phase, and measurement characteristics. Together, these findings provide a deeper understanding of the relation of vocabulary with reading and its component skills and offer further directions for research.