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This meta-analysis examines the impact of generative artificial intelligence (GenAI) tools, such as ChatGPT, on students’ academic achievement. Drawing on 53 experimental and quasi-experimental studies across educational levels and domains, we synthesized evidence from interventions using GenAI to support learning. Eligible studies reported performance outcomes (e.g., test scores, grades, GPA) and met rigorous inclusion criteria. Overall, GenAI-based instruction showed a positive effect (Hedges' g = 1.186) on academic achievement, with variation across educational level, sample size, learning domain, and the instructional role assigned to GenAI. These findings highlight GenAI’s potential as a learning support tool and offer guidance for effective implementation in educational settings.