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Guided by decades of experience conducting synthesis research, we argue in this paper for the effectiveness and usefulness of implementing qualitative meta-synthesis more broadly within education research, specifically within STEM education research. We articulate how meta-synthesis is different from other synthesis approaches and highlight the practical benefits we have experienced and witnessed while engaging in this work. Demand for high-caliber synthesis research from top-tier journals and major funders continues to grow along with the volume of educational research being published. We believe it is critical for STEM education scholars to be able to conduct well-crafted meta-syntheses that can uncover critical trends, strengthen theoretical frameworks, generate new theories, identify knowledge gaps, and inform education policy and practice.