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This study examines how Disposition toward Scientific Uncertainty Navigation (DSUN) and Epistemic Curiosity (EC), including interest-type and deprivation-type EC shape learning engagement. Survey data from 789 middle and high school students engaged in a solar energy unit taught using the Students’ Uncertainty as a Pedagogical Resource approach were analyzed using multiple regression. Both DSUN and EC positively predicted learning engagement, with significant interaction effects. Interest-type EC promoted engagement directly, while deprivation-type EC only did so when paired with strong DSUN. A three-way interaction showed that students high in both EC types were most engaged when they also had strong DSUN. These findings highlight the importance of fostering both EC and uncertainty tolerance in inquiry-based science learning.