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Little is known about how social-emotional characteristics from educational and personality psychology jointly influence educational and well-being outcomes in adolescents over time. This study integrated both perspectives to examine associations between social-emotional characteristics and well-being outcomes during secondary schooling. Ten social-emotional characteristics were: curiosity, self-esteem, academic self-concept, empathy, social interaction anxiety, and the Big Five personality traits. Four educational and well-being outcomes were: school grades, educational aspiration, school and life satisfaction. Results showed that academic self-concept and openness predicted school grades and educational aspiration. Academic self-concept, self-esteem, and agreeableness were linked to school and life satisfaction. Academic self-concept emerged as the strongest predictor in most outcomes beyond prior developmental differences.