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This study uses the OECD framework to explore the latent profiles of social and emotional skills (SES) during the middle-to-high school transition. Participants were 4,320 Chinese school students. Latent Profile Analysis (LPA) revealed four balanced profiles (extremely low SES, low SES, high SES, and extremely high SES) and one imbalanced SES profile (low collaboration and engagement). Findings showed that school environment factors (student-classmate relationships, student-teacher relationships, sense of belonging, and teacher feedback) were significantly related to SES profiles. Additionally, mental health differences (life satisfaction, relationship satisfaction, and well-being) were observed across profiles. SES profiles also exhibited a nonlinear relationship with academic achievement. These results highlight the need for long-term interventions to promote balanced SES and a positive school environment.