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Variability in practice has been introduced to leverage the effects of practice testing, and the present research aims to transfer this to multiple-choice practice testing, which is a popular format in technology-based learning environments. We propose multiple-choice practice testing exercises with variable answer options (by inversion or interchange of concepts) as a desirable difficulty to foster learning outcomes. Two laboratory experiments with N = 113 and N = 117 participants provide evidence for this assumption. Furthermore, we revealed the effects of variable answer options on indicators of deeper levels of processing and elaboration as well as metacognitive experience across thousands of practice testing exercises conducted within a digital tutoring system in two separate field experiments.