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This paper presents findings from a three-year research project examining the long-term impact of AISES, a national organization, on Indigenous students’ and professionals’ success in STEM. Using a mixed methods design informed by Tribal Critical Race Theory, the study’s methods included sharing circles, Indigenous STEM Journeys, and surveys. It engaged 110 survey respondents and 22 interviewees representing 46 Tribal Nations. Qualitative analysis suggested that AISES provided participants with culturally relevant support, material resources, and a deep sense of belonging. Quantitative analysis showed AISES engagement and belonging significantly predicted positive Indigenous STEM outcomes, including persistence. This research highlights how AISES fosters community, identity, and opportunity, supporting Indigenous individuals in STEM while strengthening ties to community and across Tribal Nations.