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Persistent concerns about the effectiveness of online learning in higher education call for a better understanding of how to support student success in virtual environments. Thus, we conducted a systematic literature review of experimental and quasi-experimental studies examining strategies for improving online learning outcomes. Drawing on 352 studies published between 2002 and 2022, we found that interventions predominantly targeted students at four-year universities, with limited attention to other contexts such as community colleges. Most interventions focused on cognitive support, while areas such as self-regulation, instructor-student interaction, motivation, and emotion received less emphasis. The predominance of positive findings across studies also suggests a potential publication bias. These insights point to both effective practices and important gaps in the current research landscape.