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This study aims to explore by comparing similar structures in pre-service science teachers' feedback loops in domain-specific and domain-general topics that can be transferred between domains through homological reasoning. In this study, the System-Based Inquiry (S-BI) protocol developed by Sweeney and Sterman (2007) was adapted and revised for use in this context. The results showed that the participants had limited homological reasoning skills. This study makes a novel contribution to science education by revealing individuals' systems thinking skills in familiar and unfamiliar areas.