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Neuroeducation, which involves teaching neuroscience-informed concepts to individuals without formal training, has seen increasing application in education but remains underexplored among primary caregivers (PCs). This systematic review examined 11 studies identified from six databases, using PRISMA guidelines and QATSDD quality appraisal. Theoretical papers emphasized shifting from information-only models to skill-based interventions, highlighting neuroscience’s potential to enhance caregiving. Empirical studies focused mostly on Pain Neuroscience Education (PNE) for caregivers of children with chronic pain, showing high satisfaction and reduced pain-related fears. One study addressed ADHD-related neuroeducation, and two qualitative studies explored how neuroscience-informed programs shaped beliefs and practices. All studies were Western-based, with few addressing early childhood. Overall, neuroeducation holds promise, but more culturally diverse, early-childhood-focused, and methodologically varied research is needed.