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This systematic review examines factors influencing goal-setting behaviors and their impact on academic performance in digital higher education, with a focus on their role within self-regulated learning (SRL). Key psychological and contextual determinants, such as self-efficacy, emotional regulation, reflection, and instructional design, shape how learners set and pursue goals. Although few studies modeled mediators or moderators explicitly, consistent patterns highlight the role of motivation, metacognitive engagement, and adaptive support. Insights emphasize goal setting as a dynamic, neurocognitive, and socially situated process embedded in SRL. The review advocates for moving beyond one-size-fits-all interventions toward personalized, motivation-sensitive digital environments. Limitations include study heterogeneity and a focus on adult online learners, indicating directions for future research.