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US Latinx adolescents face ethnic discrimination that undermines their academic motivation and mental health. Guided by García Coll’s Integrative Model and the Psychological Mediation Framework, this study quantitatively examined whether depressive and social anxiety symptoms mediated the link between perceived ethnic discrimination and educational values among 549 Latinx middle school adolescents. Findings revealed that depressive symptoms negatively mediated this relationship, whereas social anxiety symptoms unexpectedly showed a positive association with Latinx adolescents’ educational values. These results highlight the complex role of internalizing symptoms in shaping Latinx adolescents’ values placed on their education whilst contending with ethnic discrimination. Future recommendations for school and mental health providers to foster adaptive coping and resilience among Latinx adolescents facing discrimination will be discussed.