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While Social and Emotional Learning (SEL) programs have shown significant promise in supporting child development in Western contexts, few have been studied in non-Western, resource-constrained settings such as rural China. This dissertation investigates the impact of an 18-session culturally sensitive SEL program co-developed with local experts. The study seeks to 1) examine the program’s impacts on rural children's social-emotional competencies, mental health, and educational outcomes; 2) elucidate change mechanisms; and 3) identify subgroups that benefit most. Using a matched-pair, cluster-randomized design, the study involves fifth-grade students from 18 rural experimental schools and 18 matched waitlist control schools in southwest China. Contributions include advancing evidence-based practices, promoting culturally tailored interventions, fostering educational equity, and informing SEL-related policies.