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Increasing complexity in science and technology, along with the limited effectiveness of traditional lecture-based STEM education, has prompted renewed attention to active, authentic approaches to STEM learning. Based on a systematic review of 55 peer-reviewed studies following PRISMA guidelines, we identified key pedagogical strategies and learning phases common across inquiry- and research-based STEM instruction. On this basis, we present a conceptual framework, REAL-STEM (Research-Engaged Active Learning in STEM), that consists of four learning phases (orientation, conceptualization, investigation, and discussion) scaffolded by research engagement, technological affordances, and collaborative learning structures. We situate REAL-STEM in relation to established models such as 5E and POGIL, and highlight its relevance for real-world solving and conceptual understanding in high school STEM education.