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Our study strategizes the use of video-based, AI-generated instructor avatars within MOOCs to enhance learning experiences and support educational goals. We adapted Bower’s affordance analysis framework to align proposed learning tasks with the technological affordances of AI-generated avatars, in support of three iteration goals of a MOOC series: inclusivity, learner motivation, and timely scaffolding. Our study highlights promising use cases and effective design strategies for the application of AI-generated instructor avatars in online contexts. By grounding our design plan and proof-of-concept videos in educational goals, technology affordances, and contextual factors, we offer a strategic, research-informed perspective to ongoing design and scholarly discourse surrounding the use of AI tools in technology-enhanced learning environments.