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This paper reports on the results of the implementation of a model of professional Development to prepare teachers to integrate computer science into instruction for students with disabilities. This paper presents results from this design-based study to understand the factors that inhibited and enhanced teachers’ participation in the professional development and how participation in the professional development influenced teachers’ instruction and perceptions about teaching computer science to students with disabilities. Results revealed two inhibiting factors and one enhancing factor for participation. Additionally, teachers increased their integration of computer science for students with disabilities and the extent to which they designed into to support students with disabilities.