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This study aimed to explore the burnout and engagement profiles of university students (N=352) participating in an eight week ACT-based well-being intervention course and to study how the profiles differ in terms of changes in burnout risk, engagement, psychological flexibility, and well-being. The changes were measured by questionnaires at the beginning and the end of intervention. The data were analyzed with latent profile analysis (LPA), repeated-measures t-test, and repeated measures analysis of variance (ANOVA). The results showed that students represented different profiles: 1. Engaged, 2. Cynical, 3. Exhausted-engaged, and 4. Burned-out students. All of the profiles benefited the intervention, but there were differences between the profiles in the changes of burnout risk and engagement.