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Every Student Succeeds Act (ESSA) has enhanced various educational reform initiatives. Factors that influence student learning were investigated such as school climate and teacher self-efficacy. However, there is little large quantitative research that examines the relationship between them and teaching practices. This study used SEM to examine the interrelations between school climate, teacher self-efficacy, and teaching practices. The results of the U.S. data from TALIS 2018 with 2,560 secondary teachers indicated that (1) teacher self-efficacy significantly and partially mediated the relationship between school climate and teaching practices, and (2) school climate significantly and partially mediated the relationship between teacher self-efficacy and teaching practices. Implications on methodologies, theories, and practices were provided.