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We investigated the effects of constructed response prompt and format on processing of multiple complementary texts and readers’ ability to apply conceptual knowledge after reading. Participants (n = 51) were randomly assigned to conditions in a 2 (constructed response prompt: self-explain, think-aloud) x 2 (format: type, oral) between-subjects design. Students instructed to self-explain while reading five texts about natural selection produced higher quality responses than students instructed to think-aloud, regardless of whether they typed or spoke aloud. Students who produced high-quality constructed responses performed better on the knowledge posttest. Additionally, natural language processing revealed that self-explanation promoted greater cohesion in readers’ responses across texts: self-explanation helped readers construct more coherent mental representations when reading multiple texts.