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This study employed Bayesian Structural Time-Series (BSTS) models to evaluate the causal effects of Fall 2020 college openings on the county-level COVID-19 cases in 622 U.S. counties and further examined the associations between opening approaches (in-person, online, and hybrid) and county-level incidence. The results showed only 16.9% of studied counties experienced a COVID-19 case increase during the first 21 days of the Fall 2020 semester. There were no significant associations between the school opening approach (in-person, online, and hybrid) and county-level case increase. The finding revealed that those college reopening efforts and guidance could potentially minimize the risk of COVID-19 spread regardless of the opening approach.