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Guided by the intersectionality framework, this study investigated the moderating effect of the intersection of immigration status and gender in the association between school victimization and substance use. Participants include 2,795 Latinx youth from four public schools in central California. Results showed a positive association between bullying victimization and substance abuse. Additionally, among the four groups of students with different combinations of gender and immigration status, male immigrant Latinx youths were the most vulnerable to the risk impacts of victimization on substance use, followed by female U.S-born, male U.S-born, and then the weakest among female immigrant Latinx students. The finding informs the importance of considering intersection of students’ multiple identities on bullying victimization and substance use prevention/interventions programs