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Digital technologies promise unprecedented efficiency, reach, and data‑driven insight for mission‑driven organizations, yet ill‑considered adoption can erode equity and public trust. This paper examines how U.S. nonprofits can pursue comprehensive digital transformation—beyond basic digitization and workflow automation—while maintaining ethical fidelity to their communities. Drawing on sector‑wide surveys, resource‑dependence theory, and comparative case studies (charity: water, DonorsChoose, Crisis Text Line), the analysis maps four opportunity domains—operational efficiency, stakeholder engagement, data‑informed decision‑making, and virtual service delivery—against persistent barriers such as funding constraints, staff resistance, cybersecurity vulnerabilities, and mission drift. Particular attention is paid to equity challenges, including the digital divide, algorithmic bias, and recent failures (e.g., NEDA’s “Tessa” chatbot) that underscore the cost of inadequate oversight. The study proposes a five‑part strategic framework: (1) mission‑anchored leadership, (2) continuous staff capacity‑building, (3) cross‑sector partnerships, (4) inclusive design that centers marginalized users, and (5) robust governance for data privacy and AI ethics. Findings demonstrate that nonprofits embedding these guardrails from the outset leverage cloud platforms, CRMs, social‑media storytelling, and predictive analytics to amplify impact without sacrificing accessibility or trust. The paper offers actionable guidance for executives, boards, and policymakers seeking to scale responsible digital innovation across the sector.