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Over the last decade, advances in work in human genomics in Asia have been rapid and expanding. In this paper, drawing on document analysis and in-depth personal interviews with key human geneticists in Singapore and in Japan who participate in the Human Genome Organization Pan-Asian SNP Consortium, I explore the role of race and ethnicities in the Consortium’s genomic work at different stages. Three findings are highlighted: (1) “Diversity” provides a framework for pursuing potential drug “discovery”. (2) However, the interview data also show that there is no consensus on the term “ethnicity” – it is defined by the local participating scientists. (3) Ethnicity was used as a proxy for genetic diversity as an attempt to solve the problems of a disease-orientation study design and to navigate around the issue of “national genomic sovereignty.” This paper suggests the HUGO Pan-Asian SNP consortium’s work has the potential to simultaneously undermine and reify the biological bases of the traditional notions of race and ethnicity.