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The #Insulin4All movement was inspired by a lack of accessibility and affordability of insulin. This study examines Twitter data for a week surrounding an #Insulin4All rally in 2018 and provides insights into the advocacy strategies used to engage participants both online and in person. Patient advocates organized to demand transparency in the pricing of insulin by major insulin manufacturers, calling for pharmaceutical companies to explain and provide solutions to their escalating price increases for a product derived from a nearly 100-year-old patent.