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In general, studies show that chronic and heavy substance use is associated with impaired quality of life and well-being. Some substances (e.g. alcohol) have consequences that are both acute and chronic, and others (e.g. tobacco) may have negative health impact that may primarily be observed only after prolonged use. Limited studies have examined the major long-term health consequences of substance use among adolescence in general populations. Existing longitudinal work has demonstrated association between illicit drug use during young adulthood and subsequent decline in general self-reported health. In this paper we investigate the long-term association between early and prolonged substance use and various chronic conditions. Preliminary analysis shows an association over time.