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The COVID-19 pandemic encountered unprecedented drawbacks to healthcare providers, especially nurses, who endured extended exposure to trauma, inadequate protective gear, and excessive workloads. This study reviewed 25 published articles from different regions of the world to assess the prevalence of post-traumatic stress disorder (PTSD) symptoms among frontline healthcare personnel, highlighting the contributing factors that can lead to long-term effects. For this study, I selected peer-reviewed and full-text articles published in English between 2020 and 2024. The key reported symptoms include anxiety, depression, insomnia, burnout, stress, and social disengagement. These symptoms significantly affected the mental health of healthcare workers, hindering their capacity to operate effectively in both their professional and personal lives. This paper also examines the mental health effects of social distancing and isolation through various theoretical frameworks using a sociological perspective. Bourdieu's concept of social capital demonstrates how disruptions in professional and personal networks have intensified psychological distress. Goffman's dramaturgical perspectives highlight healthcare workers' challenges in managing increased front-stage responsibilities without backstage support. Furthermore, Durkheim's theory of social integration underscores the breakdown of solidarity and connections that have resulted from the isolation measures imposed during the pandemic. From a medical sociology perspective, the pandemic highlighted systemic inequalities such as shortages of resources, uneven distribution of workloads, and insufficient organizational support. These issues intensified the psychological burden on healthcare professionals. To address this challenge, comprehensive strategies are required to mitigate PTSD and enhance the resilience and long-term well-being of healthcare workers.