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Although regional food systems have long been viewed as crucial for reducing the negative environmental impacts of food and agriculture production, the regionalization of food systems has gained increased attention in the wake of global disruptions over the past decade. For example, the New England Feeding New England (NEFNE) initiative aims to have 30% of food consumed in the region produced locally. Currently, much of regional food consumption in New England occurs through alternative market channels, such as farmers’ markets, local co-ops, and community-supported agriculture programs. Since there are limits to expanding regional consumption through these channels, mainstream retailers must boost their regional procurement to enable regionalization of the New England food system. In this paper, we examine the current landscape of regional food commitments and purchases among mid- to large-sized retailers in New England, as well as the relationship between market structures, governance arrangements, and short supply chains in the region. We also discuss potential compromises associated with mainstreaming short supply chains, particularly as to sustainable farming practices. Our findings provide insights into regionalization as a strategy increase the sustainability and resilience of production systems.