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In this paper, I track the technical and philosophical commitments of "Precision Environmental Health" scientists who are committed to understanding the environmental drivers of type 2 diabetes in Latino populations. Through in-depth interviews, as well as close analysis of their research outputs (including research proposals, conference presentations, and publications to date), I examine how they are actively resisting older tropes of biological determination that social scientists previously detected in genomic research on the etiology of type 2 diabetes, as well as the challenges they face in doing so. In querying what ontology of Latinidad emerges in Precision Environmental Health Science for type 2 diabetes prevention, I also engage with previous STS literature on epigenomics and race to consider how this new science of environmental exposure and complex disease expands definitions of the “environment” itself.