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This article uses the experiences of cisgender and transgender women who take feminizing hormone replacement therapy (HRT) to theorize nostalgic and future femininities in the context of embodied change. I interview twenty one people—ten cisgender women (hereafter cis), ten transgender women (hereafter trans), and one nonbinary person—to understand their experiences with these sets of medications. I find a stark difference in the experiences of these interviewees, marked by differing relations to time, sex, and gender above all else. This difference reveals a paradox: despite HRT’s formulation as a biomedical technology to address signs of medicalized aging (menopause) for cisgender women, it is trans women and nonbinary people who are more well-versed and comfortable discussing their bodies and HRT. Cis women are less likely to feel comfortable with transition and embodied gender ambiguity in comparison to trans women. Furthermore, I highlight how HRT is integral to managing femininity as a “body project” and how the use of HRT elucidates differences in how cis and trans women orient to time.