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A growing body of research examines grandparent-provided care across cultures and countries. However, this literature has largely been organized around a framework of intergenerational co-residence. We offer a complementary framework that focuses on non-cohabiting grandparents who provide regular or occasional childcare support—a pattern that likely reflects the experience of a large share of American families. Drawing on three waves of surveys and longitudinal interviews with 139 U.S. mothers, we examine how grandparental childcare shapes work and well-being across class lines. We show that non-college-educated mothers tend to experience grandparents as financially indispensable “safety nets” who step in during crises, while college-educated mothers rely on them as flexible, on-call backup that enables longer or more stable work hours. These class-differentiated patterns of grandparental care have distinct implications for labor-market inequality and work–family conflict.