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Women engaged in street prostitution encounter many barriers when they try to leave the streets, both at the structural and the individual level. It is difficult to predict the circumstances under which an individual would be able to surmount these barriers. It is also difficult to conduct experiments to test various predictors to exiting prostitution. Simulation modeling is an innovative tool that can overcome sampling difficulties in accessing real-life populations. In this paper, I will introduce a simulation model of desistance from prostitution based on the theoretical framework of Månsson and Hedin (1999), Sanders (2007), and Baker et al. (2010). In the model, various exiting factors (e.g., drug rehabilitation, medical needs, and pimp dependence) at different thresholds would be applied to different women. The purpose of the model is to identify the patterns behind desistance from prostitution, namely what combination of factors increases the likelihood of exiting prostitution, how long does it take for such arrangements to yield results, and what individual threshold level is required. This research attempts to elaborate the theoretical foundation of the process of desistance from prostitution, as well as inform policy makers on the particular needs of rehabilitating prostitutes at different stages.