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The present research examined variation in childhood and adolescent, problem behaviors using longitudinal data from at-risk, males and females. Developmental trajectories were utilized in an effort to consider the relationship between class membership and parent criminal justice involvement, illicit substance use, and mental illness. A comprehensive understanding of childhood problem behavior and the intergenerational influence of parent criminal justice involvement, illicit substance use, and mental illness may provide the basis for targeted, problem-specific strategies aimed at early intervention.