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We examine mechanisms of static and dynamic disadvantage on trajectories of negative self-feelings by investigating effects of anger, the timing of contact with the criminal justice system, and neighborhood disadvantage. Negative self-feelings here consist of depressive symptoms, anxiety, and self-derogation. While studies show significant links between certain micro and macro-level characteristics on depressive symptoms or anxiety, results remain inconclusive about the constellation of negative self-feelings across the life course. To understand the complexities of emotional wellbeing linked to disadvantage, we consider the interplay of social psychological factors (anger), institutional (timing of criminal justice contact) and meso-level influences (neighborhood disadvantage) on negative self-feelings through the lens of a life course approach in a multilevel framework. We draw from a cohort study of individuals starting at age 11 in 1971 and following the same people up to age 40. We utilize systematic measures across twenty-nine years to better understand when and how static and dynamic factors of disadvantage affect trajectories of negative self-feelings and potential criminal behavior.