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The objective of this paper is to describe the patterns of homicide at the local level for the Metropolitan Region of Chile for the period 2001-2013. Using quantitative methodology with data provided by public health agencies, the research analyzes the distribution and characteristics of the problem, and explores associations with variables theoretically related to homicide, including protective factors (public social expenditure, crime prevention initiatives, among others) as well as risk factors that may exacerbate violence (poverty, housing overcrowding and low income households). By describing trends, patterns and correlations across municipalities within Chile, the paper offers a distinct perspective on homicide, not well reflected in US-based studies of homicide.