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In the United States, homicide rates vary across place and time. In order to study the impact of structural disadvantage on homicide rates, the theoretical framework utilized is social disorganization theory, a macro level theory. This project includes the use of primary data. Mapping and trajectories are used to describe the data and growth curve modeling is the analytical technique utilized to address the research focus. The results show that homicide rates vary not only across neighborhoods but also within neighborhoods. Additionally, the results point to the importance of social disorganization theory for studying homicide patterns over time.