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Research shows that serial sexual murderers differ from non-serial sexual murderers on a variety of factors. Yet, little is known about the differences between serial and non-serial sex offenders. Using a sample of 616 male sex offenders, we examine the differences and similarities between serial and non-serial sex offenders on developmental, personality, and criminal career variables. Findings from bivariate and logistic regression analyses indicate significant differences between serial and non-serial sex offenders in multiple aspects. Findings and implications for future research are discussed.