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Although self-control and life-course perspectives are often viewed as competing, if not incompatible, theoretical traditions, Pratt (2016) argues that the two perspectives are in many ways complementary. In his new integrated theory, self-control is viewed as a dynamic factor that is subject to change and that influences behavior over the life course, including the decreases in crime that typically come with age. In this study, we conduct a partial test of the integrated self-control/life-course theory, with a special focus on the theory’s relevance to desistance. Longitudinal data from a large study of serious youth offenders are used to examine how within-individual changes in self-control, social bonds, and other variables are related to desistance from crime. We also examine the dynamic interplay between self-control, socio-environmental variables, and desistance. The findings lend initial empirical support to the integrated theory and highlight the significance of self-control—especially changes in self-control—to the process of desistance. Implications for the future development of life course theories are discussed.