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Drawing on Agnew’s (1992) general strain theory, the current study examines the effects of Adverse Childhood Experiences (ACEs) and bullying victimization on indicators of depression, substance use, and bullying perpetration. A sample of adolescent youth between the ages 12 and 17 from the National Survey of Children’s Health (2019) was used to test various hypotheses driving the study. A number of path analyses were estimated to examine the effects of strain on negative emotions and deviance, and the models were disaggregated by gender to account for potential gendered outcomes. Results from the analyses largely support the notion that ACEs and bullying victimization are significantly associated with deviant outcomes. Likewise, increased school commitment and family resilience appears to reduce the effects of strain on delinquency. Theoretical and policy implications are discussed.