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Numerous studies have examined precursors of intimate partner violence (IPV), but less is known about factors associated with successful ‘desistance’ from such violence. Using a longitudinal cohort study the Toledo Adolescent Relationships Study (TARS), we examine objective and subjective reasons for desistance from IPV. First, using logistic regression on the entire sample, we examine whether changes in substance use, relationship quality, and criminal justice exposure are associated with IPV cessation. Second, using mean comparison on the subset of respondents who ‘desisted’, we analyze the importance of various factors to this change in their behavior. Findings indicate that a significant proportion of individuals desist from IPV; 54% of our sample reported the eventual cessation of violent incidents with their partners. Both sets of analyses revealed the role of relationship quality in IPV desistance. The regression model also indicated a significant effect of lower alcohol use. However, the second set of analyses showed that respondents viewed alcohol use as less central to their change efforts. This suggests that heightening awareness about the role of alcohol use is likely a useful component but perhaps not a ‘standalone’ focus of long-term successful reductions in IPV.