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A growing body of research has examined the nature and prevalence of missing persons across the world. This research primarily involves descriptive studies of the sociodemographic profile of people who are reported missing. Included here are studies focusing on the circumstances of disappearance, media coverage of certain case types, and particular search strategies such as Amber Alerts. Data are mainly drawn from existing national databases such as the National Crime Information Center (NCIC), the National Missing and Unidentified Persons System (NamUS), or National Center for Missing and Exploited Children (NCMEC). Studies that identify the major factors associated with increased solvability of missing person cases, however, are far less prevalent. To advance this research, the current study involves content and thematic analysis of personal interview data about the perceptions of those who work extensively with missing person cases. Key stakeholders across police and community organizations were asked about experiences with investigations, best practices, and major obstacles for solvability. The results of this study are discussed in terms of differences across circumstances and contexts. Implications for developing more effective policies, practices, and future research for enhancing the successful resolution of missing persons cases are also explored.