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A growing body of research indicates that traumatic brain injury (TBI) can have lasting effects on cognitive functioning, emotional well-being, and interpersonal relationships. However, less is known about how a history of head injury may influence students’ perceptions of safety on college campuses. Using data from the American College Health Association–National College Health Assessment (ACHA-NCHA) III, this study examines whether self-reported head injury is associated with heightened concern about personal safety in various campus settings. By recognizing TBI as a key factor, these findings can inform college health and safety programs in shaping campus security strategies and support services. Universities may be able to enhance the overall sense of safety and well-being among students by integrating head injury screenings and targeted outreach efforts.