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Social isolation, or the lack of social ties, is related to a myriad of negative health and social outcomes. Yet, many criminological theories—and empirical findings—disagree about the relationship between social isolation and delinquency, including violence. While some theories suggest isolation reduces delinquency by limiting exposure to delinquent peers, others argue it increases delinquency by weakening social bonds or creating frustration. Empirical research reflects this divide, with the exact nature of the relationship remaining unclear. This may be because current research has not fully examined the conditions under which social isolation increases or decreases violence. Using longitudinal self-report social network data, we seek to understand how social alienation may moderate the influence of social isolation on youth violence. Findings shed light on the complex relationship between social isolation and violence, with implications for prevention, intervention, and response practices for youth violence.