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Several scholars have empirically tested various aspects of general strain theory and have found significant empirical evidence for the relationships between strain, anger and criminal behavior. Moreover, several studies have demonstrated that males and females experience different negative life events, experience different types of negative affect and respond in differing ways. However, findings regarding the nature of these relationships have been mixed. The current study contributes to the existing literature by examining the differences in self-reported negative emotions and illegitimate and legitimate coping behaviors in the 30 days prior to incarceration among detained males and females with substance use disorders. We analyze cross-sectional survey data collected from 295 males and females incarcerated in a local jail located in Virginia (USA). Preliminary results indicated that females are at greater risk for exposure to risk factors and experience a wider range of stressful life events in the 30 days prior to incarceration. Females also report a wider array of negative affect and social support in the 30 days prior to incarceration. A full discussion of our results and the implications for criminological theory, correctional treatment and criminal justice policy will be presented.