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This paper proposes to center in its analysis the affective landscapes of both state agents and targets in one of the Cold War’s greatest soft power success stories: Soviet-Cuban medical exchange and cooperation. I analyse the lived experience of medical internationalism – the traffic of medical cadres, students, materials, and ideas – through Soviet and Cuban evidence, both published and archival. This paper enriches the literature on the global Cold War and on Second-Third World relations by pushing into the realms of medical internationalism and its affective impact.